Why this matters
Selectivity is the difference between a drug and a poison.
Cell death in cancer cell models is not a complete safety story. The selectivity arm of the program runs in parallel - same compounds, same conditions - on healthy fibroblasts.
- Same conditions - selectivity runs alongside the cancer arm, identical assay format.
- Healthy substrate - primary human skin fibroblasts as the negative control.
- What we observed - no cell death in healthy controls under reported conditions.
- What it does not prove - broader human safety. That work is the job of preclinical and clinical studies.
Numbers
A clean signal in a messy substrate.
0%
Observed cell death on healthy fibroblasts
Up to 100% cancer-cell death observed in selected cancer models.
Selectivity gap drives candidate ranking