MODALITIES
Peptides and vaccines as programmable modalities-chosen by target biology, delivery, immune logic, and translation burden.
Peptides bridge chemical synthesis and cell-made biologics.
Modern therapeutics fall into three broad modality families-small molecules, peptides, and large biologics-each with different manufacturing physics and trade-offs. Agemica works in the peptide band: large enough for high-specificity receptor engagement, small enough to manufacture as discrete chemistry-so ranked sequences can become synthesized, testable candidates without standing up recombinant protein production.
Peptides are short amino-acid chains-typically on the order of tens of residues-built stepwise with protecting-group chemistry. Today’s workflows lean on Fmoc solid-phase peptide synthesis (SPPS): coupling on resin, wash-away workup, and routes that scale to pharmaceutical purity. That is the operational link for Agemica-sequence edits proposed in software are the same residues encoded in synthesis, which keeps the AI→lab loop honest and fast.
- Small molecules - Low molecular weight (often under ~900 Da), frequently oral and membrane-permeable; limited binding surface area can mean noisier target engagement and meaningful off-target liability.
- Peptides - Large enough to engage receptors with biologic-like precision, yet produced by automated SPPS rather than cell culture. Agemica uses this intersection: predictable chemistry from prediction to vial on days-to-weeks cycles.
- Biologics - Antibodies and recombinant proteins offer exceptional surfaces for complex targets, but manufacturing is cell-based, costly, and typically injectable-trade-offs peptides sidestep when biology permits a designed, synthetic scaffold.
Therapeutic peptides - and peptide vaccines.
Combination therapies - approved or clinically characterized drugs selected to target shared cancer mechanisms.
Peptide vaccines - multi-epitope antigens designed to evoke a durable, selective immune response. Our platform models scale to 300+ disease targets from a single design framework.